Syneregen
$99.00
Innovita Syneregen tablets contain nicotinic acid and nicotinamide which can be metabolised into nicotinamide adenine dinucleotide (NAD+). NAD+ is essential to cell metabolism and energy generation. It is also critical to activate enzymes for DNA repair and cell regeneration. Combining with other potent antioxidants, Syneregen tablets synergistically combat the aging process.
Please contact Biogency Pty Ltd for purchase.
Innovita Syneregen tablets contain nicotinic acid and nicotinamide which can be metabolised into nicotinamide adenine dinucleotide (NAD+). NAD+ is essential to cell metabolism and energy generation. It is also critical to activate enzymes for DNA repair and cell regeneration. Combining with other potent antioxidants, Syneregen tablets synergistically combat the aging process.
Ingredients
Nicotinic acid 100mg
Nicotinamide 10mg
Leucine 500mg
Fallopia japonica extract 50mg
equiv. Fallopia japonica (Dry) 5g
(Equiv. resveratrol 25mg)
Folic acid 50mcg
Quercetin 200mg
Chromium picolinate 64.4mcg
(Equiv. chromium 8mcg)
Magnesium oxide 50mg
(Equiv. magnesium 30mg)
Directions
Adults: Take 1 tablet after meals and 1-3 times a day or as directed by your healthcare professional. Taking on an empty stomach may cause a transient harmless itchy skin and flushing reaction.
Vitamin supplements should not replace a balanced diet. If you are pregnant or breastfeeding, do not use this product. If symptoms persist consult your healthcare practitioner.
KEEP OUT OF REACH OF CHILDREN.
Store below 25°C in a dry place, away from direct sunlight.
Science
Gomes, A.P., et al., Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 2013. 155(7): p. 1624-1638.
Li, J., et al., A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science, 2017. 355(6331): p. 1312-1317.
Mouchiroud, L., et al., The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell, 2013. 154(2): p. 430-441.
Zhang, H., et al., NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 2016. 352(6292): p. 1436-1443.
Canner, P.L., et al., Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. Journal of the American College of Cardiology, 1986. 8(6): p. 1245-1255.
Lu, J., et al., Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity. The Journal of Pathology, 2010. 222(2): p. 199-212.
Kleinedler, J.J., et al., Synergistic effect of resveratrol and quercetin released from drug-eluting polymer coatings for endovascular devices. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2011. 99B(2): p. 266-275.
Why use
NAD+ precursor: as we age, the NAD+ level in the cells gradually decreases and this may lead to various metabolic disorders. Supplementation of NAD+ precursors have been proved to alleviate symptoms of aging in animal studies.
Cell regeneration: resveratrol and L-leucine have been shown to synergistically enhance the activity of SIRT1, which is the key enzyme in cell growth, metabolism and survival.
DNA repair: in addition to activate the SIRTs, NAD+ is also the fuel of DNA-repairing enzyme PARP1. The cellular level of NAD+ directly affects the activity of PARP1. With sufficient NAD+ in the cells the PARP1 enzyme could repair DNA effectively.
